BioBoost Effect™: The Discovery
Discovery of the BioBoost Effect unveils the science behind the seemingly super natural response to the Trabecular Metal Implant. The BioBoost Effect is a multiplication of naturally occurring growth factors to deliver faster healing and earlier bone formation than traditional implants.1-8
The BioBoost Effect, only available on the Trabecular Metal Implant, is the result of a proprietary combination of cancellous-like porosity and highly biocompatible tantalum.9-11 With mounting evidence of this clinical advantage in Rapid Recovery, Risk Management, and Revision Therapy cases, harness the healing power of the BioBoost Effect and take your practice to the next level.
Accelerate healing with a 2-week final loading protocol.12-15
Expand treatment in poor bone and impaired healing.16-26
Leverage the healing advantage in implant replacement.
The BioBoost Effect accelerates healing and bone formation through the multi-plication of naturally-occurring growth factors related to bone formation, wound healing,and vascularization3,6-8 Several studies have docu- mented the Trabecular Metal Implant in a 2-week ﬁnal loading protocol with a 97% to 100% survival rate after up to five years fellow up.12-14
Early bone healing and attachment through enhanced gene expression compared to traditional implants3,6
Significantly higher up regulation of growth factors related to bone healing than traditional implants3,6
97.2% survival after five years, two-week ﬁnal loading protocol12
100% survival after four years, two-week final loading protocol in extraction sites14
Several studies have shown that Trabecular Metal Implants perform well in patients with risk factors such as diabetes,rheumatoid arthritis, prior oral infection, the effects of cancer treatment and poor bone quali- ty.16-26The Trabecular Metal Implant may offer beneficial conditions for healthy implant integration in underserved patient populations.
100% survival after one year in postablative cancer patients21
97.2% survival after three years in patients with systemic disease22
Faster bone healing around Trabecular Metal Implants than tradi-tional implants in diabetic and osteopenic patients7,8
Patients with a previously failed implant are at a higher risk for another failure.27 Therefore, it is important to treat the cause of the initial failure and select the replacement implant very carefully. Unlike conventional implants, Trabecular Metal Implants offer BioBoost Technology for the healthy ingrowth of vascularized bone as well as the potential for enhanced bone healing compared to conventional titanium implants,1-8 making them an excellent choice in revision therapy.
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2. de Arriba CC, Alobera Gracia MA, Coelho PG, Neiva R, Tarnow DP, Del Canto Pingarron M, Aguado-Henche S. Osseoincorporation of Porous Tantalum Trabecular-Structured Metal: A Histologic and Histomorphometric Study in Humans. Int J Periodontics Restorative Dent. 2018;38(6):1-7.
3. Bencharit S, Barros S, Morelli T, Offenbacher S. Biological Effects of Porous Tantalum Trabecular Metal in the Oral Cavity. In Academy of Osseointegration. 2016;San Diego, CA.
4. Lee JW, Wen HB, Gubbi P, Romanos GE. New bone formation and trabecular bone microarchitecture of highly porous tantalum compared to titanium implant threads: A pilot canine study. Clin Oral Implants Res. 2018;29(2):164-174.
5. Kim DG, Jeong YH, Min KH, Lee JW, Wen HB. Porous Tantalum Increases Interfacial Bone Tissue Mineralization Compared to Titanium Threaded Section of Implants. In Academy of Osseointegration. 2016;San Diego, CA.
6. Meirelles L, Dodo C, Mendonca G, Fraser D, Sartori E, Funkenbusch P. Biomechanical analysis and osteogenic gene expression on porous tantalum implants placed in a gap healing model. Clin Oral Impl Res. 2015;26(Suppl. 12).
7. Kim SJ, Bencharit S, Morelli T, Offenbacher S, Barros SP. Transcriptomic analysis of wound healing around tantalum and titanium in diabetes. in IADR. 2017;San Francisco, CA.
8. Byrd KM, Hefni EK, Barros SP, Yu N, Kim SJ, Bencharit S, Morelli T, Offenbacher S. Transcriptomic Profiling of Tantalum Metal Implant Osseointegration in Osteopenic Patients. Accepted for publication in British Dental Journal, 2018.
9. Karageorgiou V, Kaplan D. Porosity of 3D Biomaterial Scaffolds and Osteogenesis. Biomaterials. 2005;26(27):5474-91.
10. Black J. Biological Performance of Tantalum. Clin Mater. 1994;16:167-173.
11. Matsuno H, Yokoyama A, Watari F, Uo M, Kawasaki T. Biocompatibility and osteogenesis of refractory metal implants, titanium, hafnium, niobium, tantalum, and rhenium. Biomaterials. 2001;22:1253-1262.
12. Wen HB, van der Schoor WP, van der Schoor AR, Schlee M. Immediate Nonocclusal Loading of Trabecular Metal-Enhanced Titanium Dental Implants in a Controlled Population: 5-Year Results. in The 103rd Annual Meeting of American Academy of Periodontology. 2017;Boston, MA.
13. Brauner E, Jamshir S, Di Carlo S, Pagnoni M, Guarino G, Pompa G, Immediate implant loading: a comparison of Trabecular Metal and Tapered Screw-Vent dental implants. OHDM. 2015;14(2):1-6.
14. Peron C, Romanos G. Immediate loading of tantalum-based implants in fresh extraction sockets. Long-term outcomes. in European Academy of Osseointegration. 2018;Vienna, Austria.
15. Bencharit S, Byrd WC, Hosseini B. Immediate placement of a porous-tantalum, Trabecular Metal-enhanced titanium dental implant with demineralized bone matrix into a socket with deficient buccal bone: a clinical report. J Prosthet Dent. 2015;113(4):262-9.
16. Soardi, CM, Zaffe D, Wang HL. Rehabilitation of Extremely Atrophic Maxillae with Mineralized Allograft and Highly Porous Dental Implants. in European Association for Osseointegration. 2014;Rome, Italy.
17. Edelmann AR, Patel D, Allen R, Gibson CJ, Best AM, Benharit S. Retrospective analysis of porous tantalum Trabecular Metal-enhanced titanium dental implants. Accepted for publication in the Journal of Prosthetic Dentistry, 2018.
18. Bianconi S, Bozzoli P, Del Fabbro M. Treatment of Postextraction Sites With Allograft-Stabilized Dental Implants: A Clinical Case Series. Implant Dent. 2017;26(1):37-45.
19. Schlee M, Pradies G, Mehmke WU, Beneytout A, Stamm M, Meda RG, Kamm T, Poiroux F, Weinlich F, del Canto Pingarron M, Crichton E, Poulet JB, Bousquet P. Prospective, Multicenter Evaluation of Trabecular Metal-Enhanced Titanium Dental Implants Placed in Routine Dental Practices: 1-Year Interim Report From the Development Period (2010 to 2011). Clin Implant Dent Relat Res. 2015;17(6):1141-53.
20. Tjaden A, Schlee M, van der Schoor P, van der Schoor A, Mehmke WU, Kamm T, Beneytout A, de Arriba CC, Bänninger L, Wen HB. Multicenter Studies of Porous Tantalum Trabecular Metal Implants: 4-Year Interim Results. in Academy of Osseointegration. 2016;San Diego, CA.
21. Brauner E, Guarino G, Jamshir S, Papi P, Valentini V, Pompa V, Pompa G. Evaluation of Highly Porous Dental Implants in Postablative Oral and Maxillofacial Cancer Patients: A Prospective Pilot Clinical Case Series Report. Implant Dent. 2015;24(5):631-7.
22. Peron C, Romanos G. Immediate Loading of Tantalum-Based Implants in Patients with Systemic Diseases. Clinical and Radiographic Long-Term Outcomes. Academy of Osseointegration. 2017;Orlando, FL.
23. Peron C, Javed F, Romanos GE. Immediate Loading of Tantalum-Based Implants in Fresh Extraction Sockets in Patient With Sjogren Syndrome: A Case Report and Literature Review. Implant Dent. 2017;26(4):634-638.
24. Peron C, Romanos G. Immediate Loading of Trabecular Tantalum-based Implants placed in Infected Sites with Full Ceramic Restorations. 1-year Clinical Evaluation. in AAID. 2016;New Orleans, LA.
25. El Chaar E, Castano A. A Retrospective Survival Study of Trabecular Tantalum Implants Immediately Placed in Posterior Extraction Sockets Using a Flapless Technique. J Oral Implantol. 2017;43(2):114-124.
26. Battula S, Lee JW, Wen HB, Papanicolaou S, Collins M, Romanos GE. Evaluation of Different Implant Designs in a Ligature-Induced Peri-implantitis Model: A Canine Study. Int J Oral Maxillofac Implants. 2015;30(3):534-45.
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